Endocrine Abstracts

Introduction: Previous studies have reported that SARS-CoV-2 infection is associated with a more severe disease and worse outcome in patients with diabetes mellitus. Insulin is the mainstay of diabetes therapy in the inpatient setting. However, the treatment of diabetes in patients with COVID-19 remains unclear. In this study we investigate the influence of different insulin regimens and other antidiabetic medications on glucose control and mortality in COVID-19 patients with ...

Background: Primary hyperparathyroidism (PHPT) is nowadays an asymptomatic disease characterized by mild hypercalcemia and elevated parathormone (PTH) levels. A non-typical form of the disease distinguished by high PTH levels, normal serum calcium concentrations, and no evidence of secondary hyperparathyroidism was recently identified. The data about parathyroid imaging findings in the normocalcemic type of the disease are lacking. Ultrasonography (US) is the most convenient i...

Introduction: Normocalcemic primary hyperparathyroidism (NPHPT) is a variant of primary hyperparathyroidism with consistently normal albumin-adjusted or free-ionized calcium levels. It may be an early stage of classic primary hyperparathyroidism or could represent a primary renal or bone disorder or result from another pathophysiologic mechanism leading to invariably elevated PTH levels.Aim of the study: The study aims to check and compare the FGF-23 lev...

Background: The association between primary hyperparathyroidism (PHPT) and cardiovascular disease (CVD) morbidity and mortality is well known in symptomatic PHPT patients. Atherosclerosis is considered nowadays as an inflammatory process. Elevated serum levels of acute phase proteins, C-reactive protein (CRP) and the proinflammatory cytokines tumor necrosis factor alpha (TNF α), Interleukin-6 (IL-6), as well as insulin resistance, indicating chronic subclinical inflammati...

Introduction: A syndrome of MEN2A and Hirschsprung’s disease described in Israeli Jews of Moroccan descent is caused by Cys 618 Arg mutation, one of the less common causes of MEN2A. We aimed to define the clinical characteristics of a large cohort with this mutation from a multi-center Israeli registry.Methods: The Israeli MTC registry including 8 centers was searched retrospectively for results of RET mutational analysis. Patients with a Cys 618 Ar...